Cincinnati Reds Opening Day 2025. 18—the cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. As the cincinnati reds look to the offseason to plan for 2025 there are several moves they should make in an effort to win next season.

The cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. For the reds, it will be the first opening day against the giants since 1999.